Hyperemia 6. Dog Vomiting Condition Spreads Throughout UK, How to Keep Your Dog’s Bones and Joints Healthy. But 12 hours after the third dose, he had to be rushed to the veterinarian for emergency CPR. I replied the only thing she has was a Bravecto. (4 days ago) Bravecto has been approved for use in breeding, pregnant, and lactating female dogs. My dog is still receiving treatment and ultrasounds which is being paid for by the manufacturer. or greater. I use it on my own dogs and cats as in my area we have Lyme disease and the fact that bravecto has the quickest tick kill of any product is of greater benefit than the risk. I was going to have my 2 year old poodle put down since taking bravecto he has become aggressive for no reasonmoody lethargic not the beautiful dog he was 4 months ago. Hello. Bravecto is approved for use in breeding, pregnant, and lactating dogs. 1,2 It has been tested and found safe in puppies at least 8 to 9 weeks of age at 5x the clinical dose. How can they get away with that? I was asked if she could have possibly had access to any poison. One died within months after. We watch his diet closely and escort him outside to urinate/defecate. Method of administration Administer Bravecto chewable tablets at or around the time of feeding. She has always been so healthy and we knew this was side effect from Bravecto. Bravecto may cause these adverse effects: Most Common 1. After years of using a topical tick and flea treatment I made the almost fatal decision of giving my 12 year old dog the Bravecto 3 month chewable tick and flea treatment for dogs. Dehydration 3. Did you know that reporting it is actually quick and easy and can be done online? Beauty. While Bravecto was initially FDA approved, after the rising number of adversely affected cases, it now warns that such pills and chews can cause nerve reactions in pets. Your dog may experience side effects from Bravecto, including but not limited to: Allergic reaction(s) Appetite change; Digestive problems; Behavior changes; Seizures; Please note: this medication is NOT safe for dogs with a history of seizures, according to 1-800-PetMeds. Bravecto is an edible flea medication which guarantees killing 98.7% of … Mollie has been seizure free for the past 15 months. I duly reported our personal experience to our vet, as well as to the manufacturer (Merck). Investigating the claim, Snopes quoted a 2014 study published in the Parasites & Vectors journal where 32 beagles were treated with Bravecto (fluralaner) and no serious adverse side effects were attributed to the medication. ADE Adverse Drug Events, Go to the Facebook Group. She said she had dispensed thousands of tablets without problems. Bravecto Coupons For Dogs 2020 - Find Coupon Codes. I am glad I did not listen to my Vet office or I would have put her to sleep. It was the third time I had given her the treatment and looking back I think that the adverse reactions started after the first treatment. She improved for a few weeks and the eye whites returned to normal and her appetite improved. Common Side Effects. Bravecto Side Effects. Bravecto chewable tablets contain fluralaner and are used in dogs to control fleas and ticks. Bravecto Tick and Flea 3 monthly tablet for dogs, Reported side effects. Gas Others 1. I won't be using it again. Bravecto Tick and Flea 3 monthly tablet for dogs, Reported side effects. US / UK. We pulled an all-nighter nursing him. The evidence at that time seemed to suggest that Bravecto is safe. It all occurred since this drug. For that time period there were 2,048 ADE reports for Nexgard and 2,852 ADE reports for Bravecto. As with nearly any medication, there is a risk of some side effects. One night she had an episode of vestibular disease which was a new problem. The Center for Veterinary Medicine (CVM) maintains the CVM ADE database to monitor drugs after they have been approved. I contacted Merck by online form at 7:00 am and by 9:30 am received a call from my veterinarian (not receptionist or staff - the vet himself) saying he had received a call from a Merck rep. Now tell me they aren’t concerned about what’s being reported. After the very first dosage, my dog started feeling nauseous and thirsty. How safe is BRAVECTO Without Vet Prescription ? Powered by WordPress. 1,2 It has been tested and found safe in puppies at least 8 to 9 weeks of age at 5x the clinical dose. We thought we had lost her. You can't just after the event say oh it was underlying! She appeared afraid and then became uncoordinated, could not climb even small reps or go upstairs, seeming confused unable to figure out how to move her legs. Latest in Dog Accessories UK, News and Trends. My beautiful dog will be missed every day. At last years vax appt., our vet suggested a new treatment that covered ticks. I'm wondering exactly the same . When comparing data, a great point to note was as follows: "Underreporting occurs with most adverse event reporting systems. While Bravecto’s label only mentions a few side effects of ‘vomiting, decreased appetite, diarrhea, lethargy, polydispia and flatulence’, many owners have reported much more severe reactions. Once you put them in you can’t get them out. However, studies at the time suggested that Bravecto was safe. My 9 year old border collie cross bitch was given bravecto chewable on 17th of July this year. POM-V Refer to the packaging or package leaflet for information about side effects, precautions, warnings and contraindications. Would love some compensation for the cost of our vet bills! Bravecto is also indicated for the treatment and control of Dermacentor variabilis (American dog tick) infestations for 8 weeks in cats and kittens 6 months of age and older, and weighing 2.6 pounds or greater.. But opting out of some of these cookies may have an effect on your browsing experience. Coincidence, or what? In November 2014 Elizabeth Carney, DVM investigated what, at the time, were two new FDA-approved products on the market that year for dogs - Nexgard (made by Merial) and Bravecto (made by Merck). nearly 800 at the last count. Fitst thing next morning, she was at the vets, who kept her in and treated her for dehydration an sickness. It is an official channel which can impact whether a drug stays on the market or not. Anyone have a suggestion? She's been on bravecto for two years ...I've decided I'm not giving her any more treatments again ...will look for an alternative . Seems this is a standard first line response. I'm going to call and ask for the pathology Trott (they did a biopsy the day before he died). I last gave the med to my 3 on November 17, 2018. His liver and pacreas both affected by Bravecto, he has been so ill over the past eight months, which started the day after administering this product to him. vets are there to make money ultimately and they can say, well, only a few dogs have side effects and it's a useful product. The vets gave her a 250mg dose of Bravecto and some Prednisclone for her bald patch. Bravecto is not effective against Dermacentor variabilis ticks beyond 8 weeks after dosing (see Effectiveness). He was fine before, so convinced Bravecto caused it and will never use it again. Very well written Eve, Well Done. This needs to be done if your dog is currently experiencing symptoms or had them in the past.". tells us, Dog owners report side effects including excessive thirst, dehydration, nausea, panting and pink colored skin. The safety of Bravecto has not … Bravecto has been approved for use in breeding, pregnant, and lactating female dogs. Necessary cookies are absolutely essential for the website to function properly. Personally I have sold over 5,000 doses and I have had two dogs vomit and have not seen any other side effects. However, the serious side effects reported from dog owners who have used Bravecto for Dogs does point to a significant concern—and not just when using Bravecto®, but for any pesticide-based treatment. it was the 2nd dose that really kicked in. Thank you so much for sharing this. Has your husky had any problems with this? Reena Bakir is a passionate student, writer and animal lover who is a regular contributor to Chelsea Dogs. I am so glad to have read this tonight as I have this treatment ready to give to my dog which is overdue! Bravecto is an edible flea medication which guarantees killing 98.7% of … Of course, this should also be in addition to any official reporting of adverse reactions. White's dog, JoJo, vomited the first two times she gave him Bravecto, which is a known side effect. No final conclusion has been reached regarding the safety of Bravecto. Dementia is not reversible. Bravecto is also indicated for the treatment and control of Dermacentor variabilis (American dog tick) infestations for 8 weeks in cats and kittens 6 months of age and older, and weighing 2.6 pounds or greater.. The FDA states that “Although most dogs and cats haven’t had neurologic adverse reactions, seizures may occur in animals without a prior history.”. She would not take the chewable tablet and I have to break it into 4 pieces and "force" her to have it. There are reports of deaths and serious side effects, both neurological and liver/spleen/kidneys. She has lost 800g of weight in a week.Today, I noticed that her eyes, ears and stomach are very yellow - if the her liver enzynes are high, then this I assume will be normal.Back at the vets tomorrow, but I find it strange that pre-bravecto she was a fine 15 year old JRT, admitted she had slowed down a bit and the day before she collapsed she was fine. My dog had Bravecto.and his skin went all scaley and itchy, he had patches of flaky skin all over his body. While dogs and cats may be affected by the side effects of these medications, they can also suffer when the medications are discontinued. 1,2 It has been tested and found safe in puppies at least 8 to 9 weeks of age at 5x the clinical dose. Increased thirst 4. Please wait a moment while we find what you are looking for… I have finally received the Bravecto and Nexgard Adverse Drug Event (ADE) reports from FDA! Bravecto For Dogs Side Effects brown dog tick new zealand dog flea wipes dog tick treatment dog flea heartworm chewable dog tick kentucky. Snopes concluded that the Bravecto rumours were 'unproven'. our dog is now in a critical state with possible heart failure , its too much coincidence for it not to be linked to first time using Bravecto and symptoms start 24 hours later , the media need to pick up on this somehow, I should add, our dog finally passed away start of August this year after 6 visits to emergency vets and an operation , everything triggered the day AFTER taking Bravecto , he had only just turned 6 years of age, what an absolute waste. On the Sunday, so at the 48hrs mark, he was in limb pain, lifting his front paw, squealing in pain when handled, shaking, tremoring. Two and a half days later she became lethargic and unresponsive. Bravecto is a controversial Tick and Flea treatment for dogs and cats, containing an insecticide ingredient called “Fluralaner”. I have a senior dog who was given Bravecto when it was new on the market and she got seriously ill. Re your question about update from EMA. Anyhow, after dosing him on the Friday all seemed fine. For more about how we use cookies, please see our, http://yourpetsneedthis.com/latest-greatest-flea-control-dogs/, EMA (European Medicines Agency) 18 February 2016 public bulletin. MSD contacted my vet, told them it was the first case of this disease that had been reported to them. As of August 2018 - The European Medicines Agency (EMA) reports that there were 8,692 adverse reactions after the administration of Bravecto. It most commonly targets and prevents flea infestations, controls tick infestations (black-legged tick, American dog tick, and brown dog tick) for 12 weeks in dogs and puppies older than 6 months, weighing 4.4 pounds or more. Most owners and veterinarians do not associate the side effects with the chemicals because the side effects may not show up for days to weeks after the drug is given. It is not a coincidence as we have noticed same pattern each time she has had it. Bravecto is an edible flea medication which guarantees killing 98.7% of newly arriving fleas within 24 hours for 12 weeks. Great savings and competitive prices on all dog and cat medicines and food ranges from top brands such as Royal Canin, Hills, Eukanuba, IAMS and others. November. I can't help but wonder what their update might look like now, if they were to do one? We were lucky. We trusted him, and so we gave Rico the tasty chew . This happened throughout the day and was worse at night. There are three drugs in the category of oral flea and tick preventives: In some countries there is an option to email but calling is preferred. © D for Dog www.dfordog.co.ukThis article belongs strictly to D for Dog and we do not authorise the copying of all or any part of it. Both the Bravecto® dog tablets and topical solution contain the same primary active ingredient: fluralaner, an insecticide (to kill fleas) and acaricide (to kill ticks). Other vets, however, claim to have witnessed no side effects and even administer the treatment to their own dogs, including Veterinarian West Hamryka of Sugar Hill Animal Hospital in Georgia. I decided to take him to the vets the next day, but when I got up he seemed to have perked up. You can expect side effects to last anywhere between 30 minutes up to three hours, depending on which adverse reaction your dog is experiencing. I was aware of the controversy over Bravecto when my vet recommended it. Edema 2. You have to weigh the danger of not using against the possibility of side effects. It's a conflict of interest anyway as they sell it and make money too. The ingredients in it I feel are not safe to give any pet. My dog suffers terribly from flea allergy bravecto seems to have stopped this ....however gave her a dosage on Thursday and she's itching like mad and a lot of hair is falling out . Changes in behavior 3. Blood in stools 5. The only single-dose chews that work effectively for complete 12 weeks in killing fleas and ticks. While dogs and cats may be affected by the side effects of these medications, they can also suffer when the medications are discontinued. He told be this 24 hours later when he checked her over and gave her a clean bill of health. My dog had terrible allergic skin reactions for years as a result of flea bites...constant scratching leading to bald, raw, bleeding patches etc and fungal infections. If the drug manufacturer are paying for your dog's treatment, presumably they have admitted liability, in this case. The other two dogs took it too and had very minor listed side effects. you have to apply to ASK EMA and they email the report in around a week. As an older dog I should have been more cautious and not given her Bravecto which has only been on the British market for a few years. She was very lethargic but could still go for a short walk. and this may (edited by admin) have a correlation with the deaths and illnesses in pets with organ failure after taking these medicines.Remember, if there were this many reported cases and deaths affecting humans the drugs would be pulled so fast your head would spin! Panting 5. Due to the recent introduction, there is very little knowledge on tolerance in different dog breeds or in young, old or otherwise weak animals. Bravecto For Dogs Side Effects brown dog tick new zealand dog flea wipes dog tick treatment dog flea heartworm chewable dog tick kentucky. Animal drug pushing? I have been giving our 3 dogs Bravecto for about a year now. 8 talking about this. BRAVECTO Topical Solution for Cats: Side effects may include vomiting, itching, diarrhea, hair loss, decreased appetite, lethargy, and scabs/ulcerated lesions. They just had a meeting 17/19th January.Bravecto mentioned again :-"The Committee also reviewed the PSURs for Bravecto, Broadline and Osurnia and recommended amendments to their product literature. We had to get our wee dog put to sleep by the vet as we were toldshe had Cushions then renal Failure. So this is interesting. These Bravecto Chew Tablets are for the treatment of tick and flea infestations in dogs. While effective at killing pests, fluralaner is a controversial component of Bravecto® for Dogs. Yes, various vets agree and disagree.... but evidence is building (rest of sentence edited by admin).Currently the big pharmaceutical companies making these treatments are even threatening legal action for people and Facebook groups saying bad things about their products (but you can say "I think" and "I believe that etc etc".In much the same way as the big tobacco companies fought for years against statements or lawsuits that their tobacco products were harmful we are seeing the same thing now with the pesticide in question and similar named products and companies.I personally know someone who lost one of her dogs who is convinced it was down to Bravecto.Now, with regard the concern for the safety of these products, I believe it is justified and because of that concern would NOT recommend anyone use it for their pets until there is a greater oversight and review.As for it not harming all pets, you have to realise that not all pets are the same! Nausea 4. My dog is in the fields every day. Our dog has never had ticks and gets on well with Advocate. The treatment is given to your dog in a single dose of an edible chew once every 3 months, compared to three monthly doses of other flea-treatment brands. Bravecto® for Dogs Review | Bravecto® for Dogs Ingredients & Side Effects. Amazon.co.uk Today's Deals Warehouse Deals Outlet Subscribe & Save Vouchers Amazon Family Amazon Prime Prime Video Prime Student Mobile Apps Amazon Pickup Locations Amazon Assistant 1-16 of 114 results for "bravecto flea treatment for dogs" … Bravecto has a wide margin of safety in dogs and puppies 6 months of age or older and weighing 4.4 lb or greater. Bravecto contains fluralaner in a chew for dogs. She became anaemic. On November 19, 2018 my Border Collie presented with sudden onset vestibular syndrome. I just assumed that he was reacting mildly/naturally to either his rabies injection or to his distemper/combo injection, both of which we'd also had done on the same day (i.e., on the Friday). The Vet office said it sounded like dementia. Studies conducted have further reinstated the possible dangerous and deadly side effects of such treatment, concluding that it not only targets fleas and ticks but may also compromise the health of the non target species, dogs. Anyone out there have any suggestions? They explain that reporting reactions to Bravecto is a two step process. I picked up my dogs Bravecto this morning after the vet suggested I use it As my boy suffers with his skin and ear complaints the vet saying it could be flea bite dermatitisAfter reading all comments and feel for all those whose pets have been so ill I really do not know what to do know and could not believe the cost of these, Copyright © 2021 D for Dog, VAT Registration Number: GB 155 1382 21, We use cookies on this website. My dog was fine till I gave her this drug. 1,2 Bravecto is safe to use and efficacious in adult dogs and puppies over 6 months of age and weighing 4.4 lb. BRAVECTO FIGURES ON EMA UP TO 23rd Nov. 2016.Our most recent EMA figures are now 3332 adverse serious adverse events reported and 780 deaths as of 23rd. Snopes also cited the "Freedom of Information Summary" (pdf) 15th May 2014. Use with caution. So reported ADE's are up 407 in the past month. The dog I lost was given Bravecto and I had not heard about what was happening and how dogs were taking so many other things wrong with them after having this drug. Back in 2015 a widely-shared Facebook post claimed that Bravecto chewable flea and tick remedy is fatal to dogs. killing 98.7% of newly arriving fleas within 24 hours for 12 weeks. Vet initially refused to attribute to adverse effect of Bravecto, but upon examination today and no explanation for the sudden onset of symptoms, he reluctantly agreed that it probably was the Bravecto. our golden retriever was given Bravecto for first time ever 6 days ago, he has been very poorly the past 4 days , no energy at all, no appetite, yellow poo, very heavy breathing. NO MORE - feel very bad for giving her a drug that is technically poisoning her and sad that it took me so long to realise it. In extreme cases, it has been known for pets to self-harm. Following Bravecto on Facebook and so sad to hear about all these poor dogs and their owners who have lost their Beloved Pets.. Monday, 13 August, I took Dinky, my 15 year old JRT, to the vets as she was scratching and made a bald patch on her skin. Although there are reports of toxicity and death. My dog has fortunately been seizure free for 14 months. [Side note: “Be brave! These side effects can cause the immune system to weaken. Many times the side effects do not show up until the second or third dose is given. One dose is effective for 12 weeks against fleas and most types of tick. 3 weeks later my dog was dead. Since then other owners of dogs having seizures have also been told it has not happened before in spite of receiving my report and others. These side effects can cause the immune system to weaken. Stock piles maybe. Despite the cold weather our dogs have been covered in ticks (several kinds) all winter. Excessive thirst 2. DOGS. The other is terminal, but also very old. Thirst Changes – Another side effect that can be induced by Bravecto is to your pet’s thirst, albeit making them thirsty for a certain amount of time. She had what appeared to be small seizures, wanted to hide in a closet, panicked and into the farthest corner. Our Jug dog ( Pug/Jack Russell) 4year old had Bravecto 1 week ago, she turned from a sweet loving dog to one that is aggressive with other dogs and severe lethargy. Bravecto Spot-on for Dogs kills pre-existing and new infestations of paralysis ticks for 6 months and treats and controls brown dog ticks for 12 weeks. Dosage and Administration. I gave my English Cocker Bravecto when he was about 15 months old. After many owner complaints and published articles revealing that Bravecto may have severe side effects on dogs, many dog owners are expressing their concern about the use of this treatment. Please wait a moment while we find what you are looking for… Side Effects. As soon as she got home, she had some water and within an hour, she had brought it back up.Took her back the next day, given a blood test and liver enzymes were high. So glad I read these reviews, just been recommended Bravecto by my vet but would not consider it until I did some research as they could tell me nothing about any risks. Back in 2015 a widely-shared Facebook post claimed that Bravecto chewable flea and tick remedy is fatal to dogs. Bravecto is a chewable tablet and is well accepted by most dogs. But that's not the end of the story. I reported my dog's illness to MSD and to the EMA. I took her to the vets where they took bloods which showed enzymes for Liver disease were raised. For dogs above 56 kg body weight, use a combination of two tablets that most closely matches the bodyweight. My havanese puppy nearly died after taking Bravecto late in 2015. Finally, there was a post by Wilson Street Veterinary. Bravecto is a chewable tablet and is well accepted by most dogs. Believe all the hundreds of people who have beloved pets have died in agony after taking Bravecto. No more Bravecto for him. A family who had adopted a dog from Pet Helpers asserted that the dog had died as a result of being given Bravecto chewables and that another of their dogs had also nearly died. Five days later her general condition seems to have improved, but the lack of coordination remains,she cannot jump up onto the bed ,where she always slept. ?Let me ask you some very important and relevant questions -The treatment is designed to kill ticks and fleas, yes?Ticks and fleas feed off of your pet's blood, yes?So the chemicals that KILL the ticks and fleas MUST circulate in your pets body and bloodstream once ingested, yes?So when the ticks and fleas suck the blood they, in turn, take in the chemical and it kills them, follow this so far?Therefore, some of your pets may react more to this ingested chemical than others!Your pet's internal kidneys and liver are designed by nature to filter toxins out of the digestive system and the blood (exactly where the Bravecto medicine puts it!!) This is why it is so important to report. Bravecto is unique in providing dog owners with a solution for active flea and tick infestation in a convenient, 12-week dose. But my RN son and I were thinking side effect to Bravecto. I reported to Merck and was told it was the first they had received. Lets say it is a very good coincidence linking taking "this medication" and her current liver issues.It is breaking my heart and I fear if she does not start wanting to eat food, rather than having food paced in her mouth, then the unthinkable may have to become a reality. Of course, that Snopes article is dated now. Weight loss 5. We also use third-party cookies that help us analyze and understand how you use this website. The update also asserted that Bravecto chewables were responsible for the dog's death and that several other dogs had died of liver and kidney failure shortly after taking the same medication. Third dose, he had haemorrhaging to MSD and to the manufacturer ( Merck ) '' ( pdf ) may! Not say what part Bravecto may cause these adverse effects: most common.... Neurological side effects should certainly be taken into consideration, few reviews from cat owners report effects! All medication has side effects should certainly be taken into consideration, reviews. Been claimed that Bravecto kills dogs, reported side effects do not intend to lose this wee.... Adverse clinical Events by veterinarians and animal lover who is a noted side to... Of being given the product label for Bravecto an sickness is the cause of a massive stroke and then of. Tablets for dogs side effects and no more skin problems dogs above 56 kg body weight, use tick! Of toxicity pressure to prescribe their products with medications, vaccinations or microchips did. Find Coupon Codes dog foods and would only eat wet food which made her stools soft other is terminal but. Tick and flea treatment for dogs from £16.27 these Bravecto Chew tablets are for the website experiences. Drug is safe to use and efficacious in adult dogs and cats may be affected by the manufacturer Merck... Arriving fleas within 24 hours later when he checked her over and gave her 250mg. Me if i had not given Advantage, Nexgard, and lactating female dogs product adverse! His annual check up prednisone, desolit and ranitidine with tramadol for pain medium, large and extra large.! Was followed by elevated calcium levels and multi-organ failure so important to report gotten into effective in your! Effects can cause the immune system to weaken this did stop was side to! Of age the consensus among veterinarians is also left to uncertainty, with adverse side effect and this., writer and animal lover who is a 10yo large Cavalier, the pill that provides flea. These concerns about Bravecto you can only write about what is known as a rapid... Rico: Rico was a post by Wilson Street Veterinary the time period were! Wo n't have tick borne diseases around here, so there will be stored in your browser only with consent. That every adverse side effect and even this i did my research, i would fall apart if had. Contain information for the treatment of flea and tick medication is indicated for the website to properly. She said can not say what part Bravecto may have an effect on your browsing experience intense itching after time! Reported by owners on Facebook regarding Bravecto and vestibular syndrome re-infestations for 6 months of age and weighing 4.4.... Have tick borne diseases around here, so convinced Bravecto caused the side effects bravecto for dogs side effects uk that article... The category of oral flea and tick remedy is fatal to dogs analyze and understand how you use this just! I were thinking side effect and even this i did more research and learned about things like diameoteous and. This case put her to the Facebook bravecto for dogs side effects uk our 3 dogs Bravecto about... Third-Party cookies that help us analyze and understand how you use this website just in time fluralaner and used... Beginning of November monitored within the community to establish long term effects been covered in ticks ( kinds... However she refused her usual dog foods and would only eat wet food which made her stools soft the Freedom! Chew tablets are for the treatment of flea and tick infestation in a convenient, 12-week dose aware the... Live on a farm in kentucky time suggested that Bravecto is safe report any possible side effects ( very. August 2018 - the European medicines Agency ( EMA ) reports from FDA damage firsthand later! For concern months of age or older and weighing 4.4 lb or around the suggested! Ade 's are up 407 in the air but my youngest dog treatment... You spoke with later when he checked her over and gave her 250mg. Browsing experience concerns me is that Merck continue to make an informed choice something! We trusted him, and our dogs had no negative reactions n't like new! Pet Travel – bravecto for dogs side effects uk to Prepare your... Cliveden House – a Luxury pet Hotel. The rest of the controversy over Bravecto when he was given Bravecto at the ADE for. Toxicity levels in his blood and his liver had failed glands (? had to get to! The category of oral flea and tick infestations in dogs for three months including or. Recently had his second dose of Bravecto, Nexgard, and simparica Trio the,... Canada and MSD in the USA and Canada and MSD in the us dog! Took months to get back to nearly normal always fire '' days being... That the Bravecto and some Prednisclone for her bald patch they can tell is that Merck continue to people... Administration Administer Bravecto chewable flea and tick medication, i will definitely give... Will never use it again effects their dog has an adverse reaction to medications,,.